Potentially complicating the diagnosis and treatment of these diseases is the fact that ticks may be infected with more than one agent. Recent research has shown blacklegged ticks in New Jersey to be simultaneously co-infected with disease agents for both Lyme disease and human granulocytic anaplasmosis (HGA) (2.7 to 6.0%), Lyme disease and human babesiosis (2.0%), and HGA and human babesiosis (2.0%). Lone star ticks have been shown to be co-infected with the infectious agents of Human Monocytic Ehrlichiosis (HME) (4.1%) and both Southern Tick-Associated Rash Illness (STARI) and HME (0.8%).